This article in a Korean-based journal notes that CBD patients typically have “relatively mild motor symptoms. … Our observations indicate that CBD can in rare cases present with severe episodic memory impairment associated with frontal executive dysfunctions in the early stage of illness.” This is a case report on one patient where the diagnosis of CBD has not been confirmed.
Robin
Journal of Clinical Neurology. 2008 Jun;4(2):94-8. Epub 2008 Jun 20.
Severe episodic memory impairment in a patient with clinical features compatible with corticobasal degeneration.
Kim SK, Park KW, Kang DY, Cha JK, Kim SH, Kim JW.
Department of Neurology, Dong-A University College of Medicine, Busan, Korea.
Corticobasal degeneration (CBD) is a progressive neurodegenerative disorder characterized by asymmetric parkinsonism associated with apraxia, cortical sensory loss, and alien-limb phenomenon. Neuropsychological testing in patients with CBD typically shows deficits in executive functions, praxis, language, and visuospatial functioning, but not in memory. We report a CBD patient with severely impaired memory function but relatively mild motor symptoms. Detailed neuropsychological assessment showed significant verbal and visual memory deficits accompanied by frontal executive dysfunctions. Our observations indicate that CBD can in rare cases present with severe episodic memory impairment associated with frontal executive dysfunctions in the early stage of illness.
PubMed ID#: 19513310 (see pubmed.gov for this abstract only; the abstract is available there for free)